Biological Safety

The concept of biosafety has developed with the emergence of the science of microbiology and biosafety has evolved to deal with new areas of study including recombinant DNA, molecular biology, synthetic biology, and biotechnology. As the capability to isolate, manipulate, and propagate pathogenic microorganisms matured, so too did the development of containment principles, facility design, and practices and procedures to prevent occupational exposure in the workplace and the potential release of the organisms or biotoxins to the environment.

The Department of Energy’s (DOE)' Biological Safety Program provides a forum for the exchange of best practices, lessons learned, and guidance in the area of biological safety. This content is supported by the Biosurety Executive Team that identifies biological safety-related issues of concern to the DOE and pursues solutions to issues identified.

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General Information

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Guidelines, Procedures, and Best Practices

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Training Resources

Please visit the DOE TSL Index of the IHOS SIG Website for regular training related resources. Any training related videos can be found at the Video webpage of the IHOS SIG Website.

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Tools and Other Resources

Fact Sheets



Last updated: 07/19/21

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These pages were developed under contract number DE-AC05-06OR23100 between Oak Ridge Associated Universities and the U.S. Department of Energy. For more information contact Will Artley, IH/OS SIG Coordinator, Oak Ridge Institute for Science and Education, PO Box 117, MS 10, Oak Ridge, TN 37831-0117.

Provision of this Web site by the Oak Ridge Associated Universities/Oak Ridge Institute for Science and Education (ORAU/ORISE) does not constitute endorsement of the views expressed or an endorsement or recommendation of specific commercial products, processes, services, manufacturers, or companies mentioned. The opinions and conclusions expressed are those of the authors and not necessarily those of ORAU/ORISE or the IH/OS SIG and their DOE sponsor, DOE AU-11.

The U. S. Government, DOE, or its contractors, including ORAU/ORISE or the IH/OS SIG do not warrant or assume legal responsibility for the completeness and accuracy of the information and data presented on this Web site. Some links are provided to Web sites outside of this site and should not be considered as an official endorsement or verification of the accuracy of their content. Users are subject to the privacy policies of those sites.